The Plight & Promise of p53

Emily BurkeThe WEEKLY

A Holy Grail? What if scientists could identify a mutated gene that accounts for more than half of all cancerous tumors? This gene would become a holy grail of cancer research. This gene exists, and it is called p53. The name p53 refers to its molecular mass. It is sometimes nicknamed  “Guardian of the Genome” because p53 protects cells from damaging mutations. Mutations in p53 … Read More

Biotech In Space!

Emily BurkeBiologics, Drug Development, Drug Targets, Mechanism of Action, Monoclonal Antibodies, The WEEKLY

Experimenting In Lower Earth’s Orbit Drug discovery in space? If this sounds like a page from science fiction, think again. Leading pharmaceutical companies are now collaborating with NASA to run experiments on the International Space Station (ISS). The focus on bone density, protein structure, vaccine development, immune function, and aging brings a swath of potential to this fascinating endeavor. In … Read More

Without A Treg To Stand On

Emily BurkeBiologics, Cancer, Clinical Trials, Drug Development, Drug Targets, Mechanism of Action, Monoclonal Antibodies, Small Molecule Drugs, The WEEKLY

Regulatory T-Cells Make A Pathway After our focus on T-cell activated immunotherapies revving up the immune response, we turn to the other side of the coin—a subset of helper T-cells known as regulatory T-cells. Regulatory T-cells (Tregs) suppress the immune response.  The exact mechanism by which this suppression occurs is not entirely understood, but some of the effect is due … Read More

On A Tumor’s Turf

Emily BurkeBiologics, Cancer, Clinical Trials, Drug Development, Drug Targets, Mechanism of Action, Small Molecule Drugs, The WEEKLY

TACKLING THE SPACE AROUND SOLID TUMORS Covering the science behind T-cell-based immunotherapies has been the name of the game for our past couple of issues. CAR-T and TCR therapies show significant promise in early phase blood cancer clinical trials, but what about solid tumors? Previously mentioned Juno Therapeutics’ (Seattle, WA) Armored CAR technology has declared war on tumors, and as you will read … Read More