A Killer(-T) Nobel Prize In Medicine

Emily BurkeDrug Discovery, Edited by Sarah Van Tiem, Immunology, Immunotherapy

A Killer(-T) Nobel Prize In Medicine On October 1, James Allison, now at the M.D. Anderson Cancer Center in Houston, and Tasuku Honjo, now at Kyoto University, won the 2018 Nobel Prize in Physiology or Medicine. The two scientists discovered the basis for today’s hugely successful immune checkpoint inhibitor therapies. Let’s look at their discoveries and how they have revolutionized cancer treatment. Keeping The Immune System … Read More

Attack Of The Tregs!!

Emily BurkeDrug Discovery, Edited by Sarah Van Tiem, Immunology, Immunotherapy, Inflammation

Attack Of The Tregs!! No matter what it sounds like, this subset of helper T-cells aren’t invaders from another planet. Nope, Tregs, or regulatory T-cells, come from New Jersey (don’t say it!) and elsewhere.  They suppress the immune system. These newcomers to the drug discovery and development scene intrigue the men and women seeking new approaches to diabetes, cancer, and autoimmune disorders. … Read More

Amazing Antibodies Part 2: Enlightened & Nano

Emily BurkeEdited by Sarah Van Tiem, Immunotherapy, Monoclonal Antibodies, The WEEKLY

What Can’t These Little Dudes Do? When last we met, we discussed the fundamentals of monoclonal (mAb) therapies and looked at two recent advances: antibody-drug conjugates and bispecific antibodies. This week continues our adventure in antibody innovation by introducing antibody-based photoimmunotherapy and nanobodies. Lightening Cancer Patient’s Prospects Photoimmunotherapy was conceived of at the National Institutes of Health and is being developed by Aspyrian Therapeutics (San Diego, … Read More

The Immune System: Friend & Sometimes Foe

Emily BurkeAuthor Emily Burke PhD, Biotech Basics, Edited by Sarah Van Tiem, Immune System, Immunotherapy

The Immune System: Friend & Sometimes Foe The immune system. Yes, everybody has one. It’s pretty important to our health. But what the heck is it? In short, the immune system is a complicated network of organs, cells, and signaling molecules. Without this guardian, we fall prey to dangerous pathogens and toxic substances in the environment. The immune system can … Read More

Natural Born Cancer Killers

Emily BurkeCancer, CAR-T, FDA, Immunotherapy, The WEEKLY

Further Down the Cancer Treatment Road with CARs This past August, to much fanfare, the FDA approved the first chimeric antigen receptor (CAR) T-cell therapy for blood cancer. Called Kymriah (Novartis), it promises to revolutionize treatment by genetically altering a patient’s own cells to fight cancer. Less than eight weeks later, Kite Pharma, now a part of Gilead Sciences (Foster … Read More