Picturing Disease

Emily BurkeBiotech Basics, Cancer, Clinical Trials, Diagnostics, Term of the Week, The WEEKLY

USING MEDICAL IMAGING TO INVESTIGATE DISEASE Medical imaging — using various modalities to take a snapshot of the body’s interior structure — has been around since 1895, with the discovery of X-rays by Wilhelm Roentgen. X-rays are a type of electromagnetic radiation (more on that later!) that are able to pass through soft tissues such as skin, fat, and muscle … Read More

A Skin Cell With Stem Cell Diversity?

Emily BurkeBiologics, Clinical Trials, Drug Development, Drug Targets, Term of the Week, The WEEKLY

INDUCED PLURIPOTENT STEM CELLS SHOW PROMISE Imagine being able to reprogram one of your own skin cells to produce a functioning nerve cell or section of cardiac tissue. This may sound like science fiction — but the groundwork for this to become a reality is already in the works as researchers expand their ability to create and manipulate induced pluripotent stem … Read More

Is Genetic Variety The Spice Of Life?

Emily BurkeBiotech Basics, Cancer, Cardiovascular Disease, Cocktail Fodder, Deoxyribonucleic Acid (DNA), Genetics, The WEEKLY

Understanding Basis Of Evolution Take a look at the person closest to you. Compare the color of their eyes, the texture of their hair, even the complexion of their skin to your own. Do you notice a lot of differences? Genetic variation accounts for the dissimilarities we observe between individuals—seemingly trivial ones such as the differences in eye, hair, and … Read More

Inching Across The Blood-Brain Barrier

Emily BurkeBiologics, Biotech Basics, Cocktail Fodder, Drug Development, Drug Targets, Monoclonal Antibodies, Term of the Week

A Constant Hurdle in Drug Delivery When it comes to achieving success in drug development, picking the right drug target and developing an effective inhibitor (or activator) is only half the battle. A drug candidate may appear promising in cell-based testing—and even in preclinical testing—but still fail to work in humans. It simply does not get to where it needs to be … Read More

New Brain Cells From A Pill

Emily BurkeBusiness of Biotech, Clinical Trials, Drug Development, Genetics, Small Molecule Drugs, Term of the Week

Imagine being able to regenerate your brain cells by swallowing a pill. The potential treatment relies on a process known as neurogenesis—”neuro” meaning nerves and “genesis” meaning creation. Adults suffering from neurological diseases or brain disorders may one day benefit from small molecule activators to promote the birth of neurons in the brain. Neurogenesis naturally occurs during fetal brain development and declines with … Read More

Longevity In Biotech

Emily BurkeBiologics, Business of Biotech, Cancer, Clinical Trials, Drug Development, Drug Targets, Genomics, The WEEKLY

Longevity has fascinated mankind for centuries, from ancient myths about fountains of youth to current speculation around caloric restriction. With our increased scientific understanding of aging, clinical validation and commercialization of treatments are near. The goal is to extend lifespan as well as health span, and we may be looking at a future where the norm is to remain mentally and physically active at age 90, or even … Read More

Mitochondrial Medicine Going Mainstream?

Emily BurkeThe WEEKLY

MORE THAN “JUST” A POWERHOUSE When we hear the word mitochondria, most of us remember it described in high school biology class as the “powerhouse” of a cell. It is an apt moniker, and not just because mitochondria are the subcellular compartments that convert glucose from our diet into chemical energy that our cells can use to do work. These … Read More