The Mechanics Of Melanoma

Emily BurkeBiologics, Biotech Basics, Cancer, Clinical Trials, Drug Development, Drug Targets, Mechanism of Action, Monoclonal Antibodies, Small Molecule Drugs, The WEEKLY

Spectrum Of Therapies Melanoma accounts for less than 1% of skin cancer cases yet causes the vast majority of skin cancer deaths. If detected early enough, melanoma is almost always curable. If not, its ability to metastasize makes it difficult to treat. Melanoma is more common in young adults than many other types of cancer, with 25% of new cases occurring in people under age … Read More

Harnessing Your Immune System For Good

Emily BurkeBiologics, Biotech Basics, Cancer, Drug Targets, Mechanism of Action, Monoclonal Antibodies

YOUR INNER IMMUNE WORKINGS What do monoclonal antibodies, CAR-T therapy, and checkpoint inhibitor treatments all have in common? They are immunotherapies, or therapies that activate the immune system to fight or prevent a disease. While an activated immune system can help save a life, an overactive immune system can attack the body it is charged with protecting. This over-activity is the … Read More

Breaking Bad With NSCLC & SCLC

Emily BurkeBiologics, Biotech Basics, Cancer, Clinical Trials, Cocktail Fodder, Drug Approvals, Drug Development, Drug Targets, Mechanism of Action, Monoclonal Antibodies, Small Molecule Drugs, The WEEKLY

BREAKING BAD The hit TV series Breaking Bad features anti-hero Walter White, who starts out as a sympathetic character: a mild-mannered high school chemistry teacher with a nagging cough that turns out to be lung cancer. Money problems precipitated by costly treatments, poor insurance, and a modest salary push him to start cooking up meth to ensure the financial security … Read More

Breaking Down Lung Cancer

Emily BurkeBiologics, Cancer, Clinical Trials, Cocktail Fodder, Deoxyribonucleic Acid (DNA), Drug Targets, Mechanism of Action, Monoclonal Antibodies, Small Molecule Drugs, The WEEKLY

Lung Cancer Primer The hit TV series Breaking Bad features anti-hero Walter White, who starts out as a sympathetic character: a mild-mannered high school chemistry teacher with a nagging cough that turns out to be lung cancer. Money problems precipitated by costly treatments, poor insurance, and a modest salary push him to start cooking up meth to ensure the financial security of … Read More

Immune System Checkpoint Therapies On The Case

Emily BurkeBiologics, Biotech Basics, Cancer, Clinical Trials, Diagnostics, Drug Development, Drug Targets, Monoclonal Antibodies, Term of the Week, The WEEKLY

Cancer, Meet Your Newest Opponent Immune checkpoint therapies received a lot of airtime at American Society of Clinical Oncology (ASCO) meeting in Chicago last week. The release of promising new clinical data has everyone buzzing about more cures for more cancers as a follow-on to last year’s race to the market. The hype seems to be justified. Simply put, these … Read More

First-in-Class: 2014 Drug Approvals

Emily BurkeBiologics, Cancer, Drug Approvals, Drug Targets, FDA, Mechanism of Action, Monoclonal Antibodies, The WEEKLY

The FDA ushered in six new drugs just before the close of 2014, bringing the final tally to 41– the highest rate since 1996, when the agency approved 53 drugs. 2014 drug approvals were notable not only for their quantity, but also their quality. A number of new drugs utilized first-in-class mechanisms, and new pathways always put a skip in … Read More

Biotech’s Battlefront: Monoclonal Antibodies

Emily BurkeBiologics, Biotech Basics, Cancer, Drug Targets, FDA, Mechanism of Action, Monoclonal Antibodies, Orphan Drugs, The WEEKLY

Since their premier on the scene, monoclonal antibodies (mAb) have demanded top billing on the biotech marquee, creating a cast of therapeutics used to treat diseases like autoimmune disorders and cancer. The first player debuted in 1986 when Janssen-Cilag’s OKT3 gained FDA approval to treat transplant rejection patients. Fast forward to 2013, where half of the top ten best selling … Read More